Raphael Nyarkotey Obu, The Author
I am a scientist on a mission to research and bring to the general public evidence based alternative treatments of prostate cancer.
Though conventional treatment they say is evidence based; there are thousands of researches to prove that most of these treatments are not evidence based. The problem with alternative remedies the [ads1]medical community always says is that there are no sciences or evidence supporting these claims in Ghana. So I have decided to bring to the general public the evidence of some of these treatments. Treatment is choice and no one holds monopoly on treatment and what even triggers diseases.
I entreat you the patient to make the right treatment decision by getting the right information before choosing any treatment. Do not be moved based on advertisement.
A Ghanaian Man who has good prostate health has a hundred goals; a person who doesn’t have health has but one goal. Every man has a prostate, but every prostate doesn’t have to make every man miserable. This all-too commonly bothersome gland is the source of a lot of grief as men age. So it’s a no-brainer that fighting prostate cancer depends on finding a better test. It’s the Holy Grail. We have made it top priority for our research investment at RNG Medicine Research Lab; first alternative research center in Africa to investigate and formulate evidence based alternative medicines to support the crusade against prostate health in Africa. Unfortunately, conventional diagnostics and treatment options for prostate cancer leave much to be desired. Conventional diagnosis includes PSA testing and biopsy, which are prone to false positives and carry risks of side effects. Treatment typically involves drugs, surgery and/or radiation, all of which are risky.
There ARE safer, less invasive ways to diagnose and treat prostate cancer, however, so men would be wise to investigate their options. The problem is that we are yet to have Holistic Doctors who have specialized and have conducted extensive research into Holistic Urology in Ghana but gradually we are getting there. A number of safe and all-natural strategies have been shown effective against prostate cancer, including nutritional ketosis, exercise and supplements.
It is my hope to train more specialized holistic Doctors to be able to provide evidence- based alternative treatment devoid of subjectivity. Most recently, researchers discovered a bioactive compound in the neem plant (Azadirachta indica) appears to have potent ability to quell prostate cancer.
Neem Has a Long History of Medicinal Use
The Neem leaves of seed
Taken from Review_on_Molecular_and_Chemopreventive_Potential_of_Nimbolide_in_Cancer(2014)
Neem has been used in Ayurvedic medicine for thousands of years, and the ancient Vedas refer to neem as a tree “capable of curing every illness.” It has well-established benefits for your skin, and is commonly used in personal care products. It is also used to ease gastrointestinal problems and strengthen immune function, and as both a spermicide and an insect repellent. As noted in the Biojournal of Science and Technology (BJST):
“[Neem’s] leaves, barks, fruits, seeds and roots contain compounds with proven anti-inflammatory, anti-pyretic, anti-histamine, anti-fungal, antibacterial, anti-ulcer, analgesic, anti-arrhythmic, anti-tubercular, anti-malarial, diuretic, spermicide, anti-arthritic, anti-protozoal, insect repellant, anti-feedant, anti-hormonal properties and anti-cancerous uses. …
From various research articles it can be presumed that [neem] has chemopreventive and chemotherapeutic potential against cancer models … [including] acting against the breast cancer cells, against gastrointestinal tract and associated cancers … [and] ovary cancer cells.”
Neem May Be a Potent Ally against Prostate Cancer
Now, animal research suggests nimbolide — a bioactive terpenoid compound found in neem — may shrink prostate tumors by as much as 70 percent, and suppress metastasis by about 50 percent when taken orally for three months. No noticeable side effects were observed.
According to lead researcher Gautam Sethi, Ph.D., associate professor of pharmacology at the Yong Loo Lin School of Medicine at the National University of Singapore:
“Although the diverse anti-cancer effects of nimbolide have been reported in different cancer types, its potential effects on prostate cancer initiation and progression have not been demonstrated in scientific studies.
In this research, we have demonstrated that nimbolide can inhibit tumor cell viability — a cellular process that directly affects the ability of a cell to proliferate, grow, divide or repair damaged cell components — and induce programmed cell death in prostate cancer cells …
The Lead Researchers
Direct target of nimbolide in prostate cancer is glutathione reductase, an enzyme which is responsible for maintaining the antioxidant system that regulates the STAT3 gene in the body. The activation of the STAT3 gene has been reported to contribute to prostate tumor growth and metastasis. We have found that nimbolide can substantially inhibit STAT3 activation and thereby abrogating the growth and metastasis of prostate tumor.”
Other Research Supporting Neem as an Anti-Cancer Aid
While exceptionally promising in rodents, nimbolide has not yet been tested in humans, so further research will be required. The team intends to continue investigating the compound to evaluate its efficacy in combination with commonly used prostate cancer drugs as well. That said, consuming neem either in supplement or tea form will automatically provide nimbolide. Even though the whole herb will provide only a small amount of nimbolide (compared to the straight compound given to the animals in this study), previous research has indeed found neem extract to be useful against prostate cancer. In 2006, researchers reported that.
“[A]n ethanolic extract of neem has been shown to cause cell death of prostate cancer cells … by inducing apoptosis as evidenced by a dose-dependent increase in DNA fragmentation and a decrease in cell viability … So the neem extract could be potentially effective against prostate cancer … ”
The neem tree is also considered to be a “village pharmacy” in India. Extracts of neem leaves, twigs, bark, seeds, and flowers are integral components of many traditional remedies in the Indian medical system of Ayurveda.
Chemistry of Neem
Leaves
Leaves maily yield quercetin (flavonoid) and nimbosterol (β- sitosterol) as well as number of liminoids (nimbin and its derivatives). Quercetin (a polyphenolic flavonoid) is known to have antibacterial and antifungal properties. This may perhaps account for the curative properties of leaves for sores and scabies. Limonoids like nimocinolide and isonimocinolide affect fecundity in house flies (Musca domestica) at a dose ranging between 100 and 500 ppm. They also show mutagenic properties in mosquitoes (Aedes aegypti) producing intermediates. Fresh matured leaves yield an odorous viscous essential oil, which exhibits antifungal activity against fungi (Trichophyton mentagrophytes) in vitro. White crystalline flakes obtained from petroleum ether extract of leaves consisting of a mixture of C 14, C 24, C 31 alkanes were found to exceed or equal the lavicidal activity of pyrethrum extract.
The principal constituents of neem leave include protein (7.1%), carbohydrates (22.9%), minerals, calcium, phosphorus, vitamin C, carotene etc. But they also contain glutamic acid, tyrosine, aspartic acid, alanine, praline, glutamine and cystine like amino acids, and several fatty acids (dodecanoic, tetradecanoic, elcosanic, etc.).
Neem Flower
Besides, the essential oil consisting of sesquiterpene derivatives, the flowers contain nimbosterol and flavonoids like kaempferol, melicitrin etc. Flowers also yield a waxy material consisting of several fatty acids, viz., behenic (0.7%), arachidic (0.7%), stearic (8.2%), palmitic (13.6%), oleic (6.5%) and linoleic (8.0%). The pollen of neem contains several amino acids like glumatic acid, tyrosine, arginine, methionion, phenylalanine, histidine, arminocaprylic acid and isoleucine.
Bark
The trunk bark contains nimbn (0.04%), nimbinin (0.001%), nimbidin (0.4%), nimbosterol (0.03%), essential oil (0.02%), tannins (6.0%), a bitter principle margosine and 6-desacetyl nimbinene. The stem bark contains tannins (12-16%) and non-tannin (8-11%). The bark contains anti-inflammatory polysaccharide consisting of glucose, arabinose and fructose at a molar ratio 1:1:1 with molecular weight of 8,400. The bark also yields an antitumor polysaccharide. Besides polysaccharides, several diterpenoids, viz., nimbinone, nimbolicin, margocin, nimbidiol, nimbione, etc. have been isolated from stem bark and root bark.
Besides β- sitosterol, 24-methylenelophenol and nimatone, the heartwood contains, calcium, potassium and iron salts. The heartwood on destructive distillation gives charcoal (30%) and pyroligeneous acid (38.4%). Neem wood contains cellulose, hemicellulose (14.00%) and lignin (14.63%), while wood oil contains β-sitosterol, cycloeucalenol and 24- methylenecyceloartenol.
Gum
The tree exudes a gum, which on hydrolysis yields, L-arabinose, L-fucose, D-galactose and D-glucoronic acid. The older tree exudes a sap containing free sugars (glucose, fructose, mannose and xylose), amino acids (alanine, aminobutyric acid, arginine, asparagines, aspartic acid, glycine, norvaline, praline, etc) and organic acids (citric, malonic, succinic and fumaric). The sap is reported to be useful in the treatment of general weakness and skin diseases.
Seed
Seed is very important both because of its high lipid content as well as the occurrence of a large number of bitter principles (azadirachtin, azadiradione, fraxinellone, nimbin, salannin, salannol, vepinin, vilasinin, etc.) in considerable quantities. Azadirachtin has proven effectiveness as a pesticide against about 300 insect species and is reported as non-toxic to humans.
Neem kernel lipids are similar to the normal glycerides from other oilseeds and contains oleic acid (50-60%), palmitic acid (13-15%), stearic acid (14-19%), linoleic acid (8-16%) and arachidic acid (1-3%). It is brownish yellow, non-drying oil with an acrid taste and unpleasant odour. The quality of the oil differs with the method of processing.
The composition of neem cake after the extraction of oil varies widely depending on the raw material used for expelling, for example, whole dried fruits, seeds or kernels. The range of the proximate composition in percentage are: crude protein 13-35, carbohydrates 26-50, crude fibre 8-26, fat 2-13, ash 5-18, acid insoluble ash 1-7. The bitter cake has no value as animal or poultry feed. Extraction of cake with 70% alcohol followed by hexane yields a meal free from bitterness and odour, which will be satisfactory as feed. The neem cake is rich in most of the amino acids. It is a potential source of organic manure and contains many plant nutrients, viz., nitrogen 2-3%, phosphorus 1% and potassium 1.4%. It also contains 1.0-1.5% tannic acid and has the highest sulphur content of 1.07 – 1.36% among the oil cakes. The neem cake contains a large number of triterpenoids, more of which are being discovered.
