The residents and custodians of the land are from Adoagyiri, Owuraku, Ntoaso and Akwamu.
The protestors marched to Nsawam Adoagyiri Municipal Assembly to present a petition to the government through the Chief Executive.
They want the government to stop Mrs Agyeman-Rawlings from selling the sprawling property to a private developer.
The large swathe of land was acquired by the government to grow pineapple to feed Nsawam Cannery when the factory was established.